N165 is deifinitely just a tad slow burning for the cartridge - I use a Forster long drop-tube funnel for everything though as it seems everything I load these days has the case completely full, even F/TR .308 and .223 loads!
I'd intended to use H4831 too, but with the Hodgdon powder situation, there's no guarantee of getting a season's supply, even when it reappears. (When Edgar Brothers receives its main annual shipment from the USA and word gets out that retailers have IMR / Hodgdon powders again, it'll spread like wildfire via all these electronic gizzmos I don't understand and it really will be a case of 'The Devil takes the hindmost!', at least for Varget, H4895, H4350 and probably H4831 too.) Apart from H4831, Re17 / Elcho 17 is the other obvious alternative for this cartridge, alongside Viht N560. Despite David (6mmBR)'s views on high-energy powders being fine barrel life wise, I'd rather stick with a good old single-base job having seen what N540 and N550 can do to .308 Win F/TR rifle barrels - providing the cartridge performs well enough of course. I will try Ramshot Hunter (double-base ball type) in it under 180s at some point purely to evaluate the powder.
Primers? I'll wait to hear with others with experience of the cartridge say. I'm using Russian (Murom) PMC branded primers which have a reputation like the CCI-BR2 model for being mild, but you can't get them in this country anymore.